Kyle Shanahan and the will look to pick up a home Michael Jordan Jersey win under unconventional circumstances in Week 13. The 49ers host the on Monday Night Football, though the game will take place a long way from San Francisco after a move to Glendale, Arizona. San Francisco enters on a high note, however, with an upset win over the in Week 12. Buffalo is also playing well, winning four of the last five games, including a victory over the a week ago.Kickoff is at 8:15 p.m. ET. William Hill Sportsbook lists the 49ers as two-point favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 47.5 in the latest 49ers vs. Bills odds. Before you make any Bills vs. 49ers picks and predictions, .The model, which simulates every NFL game 10,000 times, is up more than $7,900 for $100 players on top-rated since its inception five-plus years ago. It is a sizzling 20-10 on top-rated this season, returning almost $900. The model also enters Week 13 on an incredible 116-75 Bradley Beal Jersey run on top-rated NFL picks that dates back to the 2017 season.The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up. Now, the model has set its sights on . You can . Now, here are several and trends for Bills vs. 49ers: Bills vs. 49ers spread: 49ers -2Bills vs. 49ers over-under: 47.5 points Bills vs. 49ers money line: Bills +110, 49ers -130BUF: Bills are 5-2 against the spread in non-division games SF: Under has hit in two straight Niners gamesWhy the Bills can cover Buffalo ranks No. 8 in Ish Smith Jersey the NFL in touchdown pa ses allowed (16) and is No. 8 in sacks (30), generating a consistent pa s rush. Given that San Francisco isn't a dynamic pa sing team, the Bills match up well, and the 49ers have the sixth-fewest touchdown pa ses (14) and the fifth-most interceptions (12) in the league this season.In addition, the 49ers are a bottom-10 team in the league on third down, converting only 40.2 percent of the time, and the Bills should be able to limit damage as a result. Why the 49ers can cover Injuries have been an i sue for the 49ers this season but, despite limited personnel, the team's defense has been lights-out. San Francisco is No. 6 in total defense, giving up only 315.2 yards per game, and No. 4 in pa s defense, allowing 206.5 yards through the air.With a strong secondary and a solid scheme, the 49ers rank in the top 12 of the NFL in completion percentage allowed (64.6), yards per pa s attempt allowed Washington Wizards Hats (6.9), pa ser rating allowed (89.2) and interceptions (10).Against the run, San Francisco is also effective, giving up only 4.0 yards per carry and 108.7 yards per game. All told, the 49ers are an above-average scoring defense, with opponents scoring only 23.1 points per game, and have strong personnel, with generating 7.5 sacks and ranking near the top of the league with 85 total tackles. How to make 49ers vs. Bills picks SportsLine's model is leaning Over on the total, with the model projecting 49 total points. Washington Wizards Jeresy The model also says one side of the spread hits in well over 50 percent of simulations. .So who wins Bills vs. 49ers on Monday Night Football? And which side of the spread hits in well over 50 percent of simulations? , and find out.